Potential new treatment for traumatic brain injury – the female hormone progesterone

traumatic brain injury progesterone trial
By Patrick J. Lynch, medical illustrator via Wikimedia Commons

Traumatic brain injury (TBI) has been headline news this January.  As I’m writing this, Michael Schumacher is still in a medically induced coma after suffering a traumatic brain injury skiing. And here in Sydney, we’re all reeling after the death of a teenager, Daniel Christie, who tragically had his life support switched off last week. He suffered a TBI after a single, random punch knocked him to the ground and fractured his skull when he was out celebrating New Year’s Eve in Sydney.

Traumatic brain injury has no standard drug treatment

Some of the damage from a TBI is caused at the time of the injury. But it’s the subsequent ‘cascade’ of events — brain swelling, free radical formation, and inflammation— that worsen that initial injury.

It goes without saying that finding effective, inexpensive and widely usable treatments for brain injury is really, really important.

Sadly, no drug treatment has been shown to improve recovery from TBI.

Methylprednisolone (a steroid) was once considered a mainstay of treatment, but it’s proven to be harmful, not helpful.  Currently the only treatment involves surgery to reduce swelling and to remove blood clots, and attempts to keep the brain oxygenated.

Serendipity in science – progesterone protects brain cells

The search for a safe and clinically effective drugs to prevent secondary brain damage after TBI has uncovered a new prospect – the hormone progesterone.

Yes, progesterone! The female reproductive hormone.

It turns out that progesterone is present in the brains of men and women in small, roughly equal concentrations. And it’s not just made in the gonads and adrenal glands, but also produced by glial cells in the brain, and by the Schwann cells that provide insulation to nerves.

Some of the first clues that progesterone might be neuro-protective came from serendipitous observations of the differences between males and females recovering from stroke or brain injury.

Two things were noted:

1) Older women and post-menopausal women recover worse than men from stroke.

2) Female rats recover from TBI better than male rats.

It appeared that there was some association between gender, the menstrual cycle, and recovery from brain injury.  These observations eventually led to the development of progesterone as a neuro-protective drug.

How does progesterone protect against damage?

Scientists have suggested a number of ways progesterone might protect the brain:

  • reduce brain swelling
  • enhance antioxidant mechanisms
  • reduce brain cell death from electrical over-stimulation (excitotoxicity)
  • reduce immune inflammation
  • provide neurotrophic (growth and survival) support
  • stimulate myelin (insulation) regrowth around axons
  • promote new synapse formation (brain cell connections)
  • enhance dendritic arborisation (growth of new neural processes)
  • impact blood vessel function and blood pressure
  • reduce core temperature (an increase in core temperature increases the risk of brain damage).  It is thought that giving progesterone to TBI patients may change blood pressure or core temperature – but the results are still out on this one.

The bonus of progesterone is that it does not target one single aspect of the TBI cascade, instead it works through multiple mechanisms to enhance the repair of damage to nerve cells caused by CNS injury.

Clinical trials for progesterone and TBI

Two randomised, double-blind, placebo-controlled phase II clinical trials of progesterone for TBI patients have been conducted. Both studies have shown that progesterone decreases in mortality (rate of death) and reduces the level of disability of patients who recover. The studies also confirmed that the drug is safe and tolerated by the head injury patients.

The only problem is that these were phase II trials, so they were small and done at individual sites.  So right now, two phase III trials are underway which are much larger and comprehensive:

  • SyNAPSe is a global study (but doesn’t include Australia)
  • PROTECT III is a trial in the US only.

The trials are testing if progesterone along with standard medical care works better than standard medical care alone to limit damage from TBI.

If progesterone helps brain injury patients get better, it will be a big improvement in the treatment of TBI, because right now, there is very little that can be offered.


Useful links:

Cochrane summary: Progesterone for traumatic brain injury

Open Access paper: Wie & Xiao 2013  The neuroprotective effects of progesterone on traumatic brain injury: current status and future prospects
. Acta Pharmacologica Sinica (2013) 34: 1485–1490.

Protect III  trial 

SyNAPSe trial

 

ResearchBlogging.org

Jing Wei, & Guo-min Xiao (2013). The neuroprotective effects of progesterone on traumatic brain injury: current status and future prospects
 Acta Pharmacologica Sinica DOI: 10.1038/aps.2013.160

8 Responses to Potential new treatment for traumatic brain injury – the female hormone progesterone

  1. Well, calling it a female hormone is a bit of a misnomer. Sure, it’s well known as a regulator of ovulation, but it’s an important neurosteroid and a very important intermediary in other steroid hormone biosynthetic pathways (androstenedione -> testosterone -> – if aromatase is present – estradiol). So it’s a very important male hormone as well!

    • What a shame to hear this Ryan:

      “Statement on the Termination of the ProTECT Trial

      On January 15, 2014, the NINDS announced that its phase III ProTECT (Progesterone for Traumatic brain injury–Experimental Clinical Treatment) trial stopped enrollment. 875 participants were enrolled in the trial. The trial was designed to determine if progesterone, a steroid known to have neuroprotective properties in animal models of brain injury, could be beneficial in treating patients with moderate to severe acute traumatic brain injury.

      The ProTECT trial was stopped after the independent Data and Safety Monitoring Board determined that the data indicated it was very unlikely that progesterone treatment would demonstrate better outcomes compared to a placebo control in this trial.

      The NINDS is extremely grateful to the patients who participated and the investigators who worked so hard on this high-quality clinical trial. The scientific community remains dedicated to develop better treatments that will decrease the burden of illness due to the traumatic brain injury, which affects 1.5-2 million people in the US each year.”

      http://www.ninds.nih.gov/research/tbi/

  2. The article says one way progesterone helps is that it will “reduce core temperature (an increase in core temperature increases the risk of brain damage).” This is incorrect, as progesterone in the female increases core temperature. This is how you know you’ve ovulated: by a rise in core temperature (or by a blood test to determine progesterone levels).

  3. I watched all the ‘proTECT’ videos in the days after my stepson’s TBI, and I applied my own progesterone cream to him while he was in a coma. The brain swelling had been increasing for four days and he was in a dire situation – and we were prepared by hospital staff for the worst. Four hours after I applied the cream the first time, the swelling began to come down. The turnaround was so stunning, he was conscious the following day.
    I don’t care what clinical trials say – I watched it work.

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