Fearful memories reinforced by the stress hormone cortisol.

PTSD, stress, cortisol, memory

Fearful memories are reinforced by the stress hormone cortisol.

We’re all more likely to remember events that have great emotional significance: the birth of a child or the first time you met the love of your life.

But bad memories seem to stick more than good.

Memories of emotional experiences usually fade over time

Strong memories of stressful experiences tend to decline over time. But people suffering from anxiety or Post-Traumatic Stress Disorder (PTSD) are affected by terrifying memories that haunt them again and again. In these instances the memory trace remains strong, leading to clinical symptoms such as intrusive thoughts, re-experiencing (reliving the event vividly) and fear.

Therapy can extinguish traumatic memories

Any new memory is initially fragile and susceptible to interruption until they become ‘consolidated’. But reactivated memories can also be brought once again to a temporary fragile state. During this period, the reactivated memory can be enhanced, impaired, or otherwise updated by various pharmacological or behavioural interventions.

Although therapy can lead to formation of a new, safe memory (e.g., in exposure therapy), the original aversive memory is not affected which is why many people with PTSD relapse after treatment. It’s been suggested that if the original emotional memory itself could be weakened, the return of fear after successful treatment might be prevented.

Cortisol, the amygdala and memory formation

Cortisol is a potent modulator of learning and memory processes. It acts on neurons in the amygdala to enhance memory consolidation for emotional events. Interestingly, its effective not only while the memory is being formed for the first time, but also later when people look back at an experience while the memory reconsolidates.

To investigate how cortisol affects the reconsolidation of fear memories in humans, cognition psychologists from the Ruhr-Universität Bochum undertook a cortisol-stress experience.  The results published in the journal Neuropsychopharmacology might explain the persistence of strong emotional memories occurring in anxiety and PTSD.

The stress-cortisol experiment

On three consecutive days, the subjects took part in the study, carried out by Shira Meir Drexler, PhD student at the International Graduate School of Neuroscience in Bochum.

  • On the first day, they learned an association between specific geometric shapes and an unpleasant electric shock.
  • On the second day, some of the participants were given a cortisol pill, others a placebo. Subsequently, they were shown one of the geometric shapes associated with the electric shock.
  • On the third day, the memory for the geometric shapes was tested. Participants who had taken cortisol remembered the fear-associated shape particularly well. This was evident in a heightened skin conductance, which is an established measure for emotional arousal.

Cortisol enhances reactivated fear memories.

The researchers demonstrated that cortisol impacts memories in humans during memory reconsolidation.

“The results may explain why certain undesirable memories don’t fade, for example in anxiety and PTSD sufferers,”

says Prof Dr Oliver Wolf.

“Reconsolidation processes are triggered by a brief memory reactivation. The reactivated memory then becomes labile for a limited period of time, andif not interruptedreconsolidates and remains intact. Interrupting the re-activated memory at this fragile state might change (impair, enhance, or update) the original memory tracepotentially preventing the return of fear in anxiety disorders and PTSD.”

“Put together with previous studies, our results suggest cortisol to be of potential benefit in exposure-based (but not reconsolidation-based) therapies.”


Drexler et al, Neuropsychopharmacology. 2015 Jun 10. doi: 10.1038/npp.2015.160. [Epub ahead of print] Effects of Cortisol on Reconsolidation of Reactivated Fear Memories.
Story Source:  materials provided by Ruhr-Universitaet-Bochum.

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